Molecule Monday: Androsta-3,5-diene-7,17-dione (Arimistane)

Today I'm going to talk about an aromatase inhibitor that I saw in quite a few products. Androsta-3,5-diene-7,17-dione, also known as Arimistane, is a pretty strong OTC aromatase inhibitor (aromatase is the enzyme that converts androgens into estrogens). This compound is a metabolite of DHEA (dehydroepiandrosterone), which is the most common endogenous steroid hormone in the body, and 7-keto-DHEA. It's been shown to have a very high binding affinity to aromatase, with a Ki value of around 0.2 uM, (the lower the better) roughly half of the formally sold aromatase inhibitor 6-OXO. It acts as a suicide inhibitor, meaning it irreversibly binds the aromatase and renders it inactive.  This can be very beneficial to people either taking androgens that can convert to estrogen, or taking it when coming off androgens, to control estrogen rebound levels. Another interesting property of this compound is that it may also lower cortisol. The keto group on carbon 7 may act as a hydride acceptor (H-) from the the enzyme 11-betahydroxysteroid dehydrogenase(11-bHSD) which is responsible for turning inactive cortisone into active cortisol. A little bit of cortisol is beneficial, while chronic elevated levels can break down muscle. Based on it's structure and being a 7-keto-DHEA derivative, it may also have some of the same properties like increasing LH and decreasing sex hormone-binding globulin, although more research is needed. Overall, for an OTC compound, it may have some benefit for athletes.  This compound can be found in Eradicate and PCT V by @blackstonelabs #musclechem


The Guerrilla Chemist
The Guerrilla Chemist

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The Guerrilla Chemist was created to inform anyone from fitness enthusiasts to hardcore bodybuilders about the science of sports nutrition supplements. The sports nutrition industry is constantly releasing new products, some of which have insane claims. My mission is to bring you cutting edge research and the bottom line about all products aimed at building muscle or burning fat.