Molecule Monday: Alpha-glycerylphosphorylcholine(alpha-GPC)

Happy #moleculemonday! Alpha-glycerylphosphorylcholine(alpha-GPC) is an interesting molecule that has some interesting properties. It's a precursor to the neurotransmitter acetylcholine, which may improve cognitive function, and it can readily cross the blood-brain barrier(BBB). Many supplement companies are including it in preworkout formulas bc of 2 studies that came out last year. One study showed athletes taking 600mg 45min prior to working out noticed a 14% increase in power. The second study is the one I find more interesting. Subjects receiving 1000mg of alpha-GPC had a 221% increase in GH levels 60 min after ingestion. While it doesn't raise GH levels all day, it can cause a huge spike right around a workout or post workout which may be beneficial for repairing muscle tissue. Another study showed a 168% increase in GH after 45 min at a dose of 600mg. Bottom line: acetylcholine is involved in tons of biochemical processes and can play a major role in everything from cognitive function, to fat oxidation, to muscle repair. Alpha-GPC is the most effective choline precursor on the marker and may have some ergogenic properties worth looking into. Alpha-GPC stacks very well with racetams and noopept, as they inhibit the breakdown of acetylcholine. My personal favorites are phenylpiracetam and noopept, however I have not tried certain ones, like oxiracetam.

The Guerrilla Chemist
The Guerrilla Chemist


The Guerrilla Chemist was created to inform anyone from fitness enthusiasts to hardcore bodybuilders about the science of sports nutrition supplements. The sports nutrition industry is constantly releasing new products, some of which have insane claims. My mission is to bring you cutting edge research and the bottom line about all products aimed at building muscle or burning fat.