Molecule Monday: Bioperine

Happy #moleculemonday! There's a new compound popping up in a lot of preworkouts, but it's not some new crazy stimulant. Bioperine, or black pepper extract is a potent inhibitor of the enzymes CYP3A4 and P-glycoprotein. These enzymes are responsible for breaking down many important fat burning molecules such as caffeine and catecholamines(norepinephrine), as well as cortisol and androgens. Essentially, by adding Bioperine to a preworkout, not only does it vastly increase the bioavailability of these molecules, it also prolongs their half-life, making them more active for longer periods of time. This means you can effectively take less caffeine and other stimulants, while having the effects of taking a higher dose. Worth noting-a 2006 study showed subjects taking Bioperine while fed a high fat diet showed significantly reduced plasma lipid and LDL(bad cholesterol) levels. Subjects also had significantly elevated levels of HDL(good cholesterol), as well as T3, T4 and testosterone. Most products contain 5mg of a 95% black pepper extract. If your preworkout contains high levels of caffeine or catecholamines and doesn't have Bioperine, I highly suggest adding it.


Bioperine can be found in Blackstone Labs' own Cobra-6P and Cobra-6P Extreme products. 


The Guerrilla Chemist
The Guerrilla Chemist


The Guerrilla Chemist was created to inform anyone from fitness enthusiasts to hardcore bodybuilders about the science of sports nutrition supplements. The sports nutrition industry is constantly releasing new products, some of which have insane claims. My mission is to bring you cutting edge research and the bottom line about all products aimed at building muscle or burning fat.